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(sef´lek´sin) n brand names: Ceporex, Keftab, Keflex; Drug class: first-generation cephalosporin; Action: inhibits bacterial cell wall synthesis, rendering cell wall osmotically unstable; Uses: removal of gram-negative bacteria (bacilli) from the upper and lower respiratory tracts, urinary tract, and skin; treatment of bone infections and otitis media.

A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive bacteria and less active against gram-negative bacteria (organisms).

glossary/cephalexin.txt · Last modified: 2012/10/16 14:40 (external edit)